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Does the use of inhaled corticosteroids in asthma benefit lung function in the long-term? A systematic review and meta-analysis.
Tan, Daniel J; Bui, Din S; Dai, Xin; Lodge, Caroline J; Lowe, Adrian J; Thomas, Paul S; Jarvis, Deborah; Abramson, Michael J; Walters, E Haydn; Perret, Jennifer L; Dharmage, Shyamali C.
Affiliation
  • Tan DJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Bui DS; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Dai X; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Lodge CJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Lowe AJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Thomas PS; Faculty of Medicine, University of New South Wales, Randwick, Australia.
  • Jarvis D; National Health and Lung Institute, Imperial College London, London, UK.
  • Abramson MJ; School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia.
  • Walters EH; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Perret JL; School of Medicine, University of Tasmania, Tasmania, Australia.
  • Dharmage SC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Eur Respir Rev ; 30(159)2021 Mar 31.
Article in En | MEDLINE | ID: mdl-33472957
While asthma is known to be associated with an increased risk of progressive lung function impairments and fixed airflow obstruction, there is ongoing debate on whether inhaled corticosteroids (ICS) modify these long-term risks. Searches were performed of the PubMed, Embase and CENTRAL databases up to 22 July 2019 for studies with follow-up ≥1 year that investigated the effects of maintenance ICS on changes in lung function in asthma.Inclusion criteria were met by 13 randomised controlled trials (RCTs) (n=11 678) and 11 observational studies (n=3720). Median (interquartile range) follow-up was 1.0 (1-4) and 8.4 (3-28) years, respectively. In the RCTs, predominantly in individuals with mild asthma, ICS use was associated with improved pre-bronchodilator (BD) forced expiratory volume in 1 s (FEV1) across all age groups (2.22% predicted (95% CI 1.32-3.12), n=8332), with similar estimates of strength in association for children and adults. Improvements in post-BD FEV1 were observed in adults (1.54% (0.87-2.21), n=3970), but not in children (0.20% (-0.49-0.90), n=3924) (subgroup difference, p=0.006). Estimates were similar between smokers and nonsmokers. There were no RCT data on incidence of fixed airflow obstruction. In the observational studies, ICS use was associated with improved pre-BD FEV1 in children and adults. There were limited observational data for post-BD outcomes.In patients with mild asthma, maintenance ICS are associated with modest, age-dependent improvements in long-term lung function, representing an added benefit to the broader clinical actions of ICS in asthma. There is currently insufficient evidence to determine whether treatment reduces incidence of fixed airflow obstruction in later life.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Adult / Child / Humans Language: En Journal: Eur Respir Rev Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Adult / Child / Humans Language: En Journal: Eur Respir Rev Year: 2021 Document type: Article Affiliation country: Country of publication: